Overview
LFIRE™ allows for the precise, real-time measurements of specific interactions between molecular entities in a microarray or well-plate format. These molecular entities can be proteins, nucleic acids, lipids, small molecules such as drugs or steroids, or even whole cells. As a "label-free" detection system it avoids alterations of the molecules from the labeling procedures used in fluorescent systems and directly reduces labor and materials costs associated with tagging. As a "real-time" system, it monitors reactions as they happen, providing information about a sample before and after equilibrium. This additional information is necessary for increasing the dynamic range of concentration measurements, optimizing biological assays and analyzing kinetic activity critical to drug research.
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